fibroblast growth factor receptor1

Bogaziçi Üniversitesi

Prof. Dr. Kuyaş Buğra

E-mail: bugra@boun.edu.tr

EDUCATION:

1986 PhD, Department of Biology, University of California, Los Angeles, USA.

1975 Higher Licence in Biology, Hacettepe University, Ankara, Turkey.

HONORS AND AWARDS:

1992-1993 Servie, Research Fellowship
1990-1991 Ipsen Foundation, Research Fellowship
1989-1990 Fondation Recherche Medical, Research Fellowship
1988-1989 INSERM, Poste Vert
1987-1988 Fight for Sight Foundation, Postdoctoral Fellowship
1986-1987 Retinitis Pigmentosa Foundation, Postdoctoral Fellowship
1982-1986 NATO Graduate Fellowship
1980-1982 Chancellor's Patent Fund Research Grant

TEACHING EXPERIENCE

June 2002 - present
Chair,
Department of Molecular Biology and Genetics, Bogaziçi University.

1994 - present
Full Professor,
Bogaziçi University Department of Molecular Biology and Genetics, Istanbul.

1982-1986 Teaching Associate,
Department of Biology, UCLA, Los Angeles. Genetics, Molecular Biology.

1982 Visiting Professor,
Chapman College, Los Angeles.

1980-1982 Teaching Assistant,
Department of Biology, UCLA, Los Angeles.

1975-1977 Teaching Assistant,
Department of Biology, Middle East Technical University, Ankara.

RESEARCH ACTIVITIES

1994- Study of the expression fibroblast growth factor, fibroblast growth factor receptor, neurotrophin, neurotrophin receptor gene families during development of mammalian retina. FGF signal transduction pathway in rat retina. Bogaziçi University.

1991-1993 Analysis of the expression of fibroblast growth factors, their receptors and the transcription factors during experimentally induced epilepsy. INSERM U. 29.

1988-1991 Study of the acidic fibroblast growth factor gene and its expression in normal and mutant rats. INSERM U. 118.

1986-1988 Cloning and the analysis of photoreceptor cell specific genes. Neurophyschiatric Institute, UCLA.

1977-1986 Identification and cloning of the surface antigens of Schistosoma mansoni. Department of Biology, UCLA.

PUBLICATIONS:

1. Ergörül, C., Çayirlioglu, P., Çinaroglu A., Genç, B., Hicks, D., Bugra, K. Expression and Cellular Localization of FGF9 in Developing Rat Retina. (In preperation)

2. Bugra, K., Hicks, D., 1997. Acidic and basic fibroblast growth factor messenger RNA and protein show increased expression in adult compared to developing normal and dystrophic rat retina. J. Mol. Neurosci 9:13-25.

3. Bugra, K., Polard, H., Charton, G., Moreau, J., Ben-Ari, Y., Khretschatisky, M., 1994. Kainate induced seizures elicit rapid increase of aFGF and bFGF mRNA in lesion resistant neurons of the rat hippocampus. Eur. J. Neurosci., 6: 58-66.

4. Jaquemin, E., Jonet, L., Oliver, L., Bugra, K., Laurent, M., Courtois, Y., Jeanny, J-C., 1993. Developmental regulation of acidic fibroblast growth factor expression in bovine retina. Int. J. Dev. Biol. 37:417-423.

5. Bugra, K., Olivier, L., Jacquemin, E., Laurent, M., Courtois,Y., Hicks, D., 1993. Acidic Fibroblast Growth Factor is Expressed Abundantly by Photoreceptors Within the Developing and Mature Rat Retina. Eur. J. Neurosci., 5: 1586-1575.

6. Malecaze, F., Mascarelli, F., Bugra, K., Fuhrmann, G., Courtois, Y., Hicks, D., 1993. Fibroblast Growth Factor Receptor Deficiency in Dystrophic Retinal Pigmented Epithelium. J. Cell. Physiol., 154: 631-642

7. Renaud, F., Deset, S., Bugra, K., Halley, C., Philippe, J-M., Courtois, Y., Laurent, M., 1992. Heterogeneity of 3' untranslated region of bovine acidic FGF transcripts. Biochem. Biophys. Res. Comm., 184: 945.

8. Bugra, K., Jacquemin, E., Ortiz, J., Jeanny, J.C., Hicks, D., 1992. Analysis of opsin mRNA and protein expression in adult newt retina by immunology and hybridization. J. Neurocytology 21: 171.

9. Hicks, D., Bugra, K., Faucheux, B., Jeanny, J-C., Laurent, M., Malecaze, F., Mascarelli, F., Raulais, D., Cohen,Y., Courtois,Y., 1991. Fibroblast Growth factors in the retina. In: Progress in Retinal Research, eds. Osborn, N. N. and Chader, G.J. Pergamon Press, Oxford, UK, vol 11: 333-374.

10. Hicks, D., Malcaze, F., Mascarelli, F.,Bugra, K., Courtois, Y., 1991 Fibroblast growth factor in photoreceptor-retinal pigment epithelium interactions. In "Retinal Degenerations" eds. Anderson, R.E., Hollyfield,J., La Vail, M.M., pp: 87-99. CRC Press.

11. Tsuda, M., Syed, M., Bugra, K., Whelan, J., McGinnis, J.F., Shinohara,T., 1988. Structural analysis of mouse S-antigen cDNA. Gene 73: 11.

12. Baehr,W., Falk, J.D., Bugra, K.,Triantafyllos,J., McGinnis,J.F., 1988. Isolation and analysis of the mouse opsin gene. FEBS Let 238: 253-256.

13. Bugra, K., Tanaka, R.D., Boyle,W.J., MacInnis, A.J., 1983. Isolation of polyA+ RNA from S. mansoni and immunoprecipitation of its translation products. J. Parasitol 69:486-490.


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