fibroblast growth factor receptor1

Bogaziçi Üniversitesi

Research Interests

Our main purpose is to reveal the molecular mechanisms of FGF9-signalling pathway in Müller cells. Current studies are focused on the identification of novel FGFR-cytoplasmic ligands and phosphorylation analysis of main receptor tyrosine kinase signaling pathway proteins.

We are focused on the effects of Fibroblast Growth Factor (FGF) protein family, especially FGF9, on the development and phsyiopathology of mammalian retina.

Roles of aFGF (FGF1) and bFGF (FGF2), mostly known members of FGF family, in development of retina are well studied. Our experimental results about the expression levels of FGF9 through postnatal development of rat retina indicates that this factor may be involved in retinal specific cell birth, cell migration and differentiation. Therefore, we believe that FGF9 may have different role(s) other than aFGF and bFGF have.

Histochemical analyses have shown that FGF9 is mainly found in photoreceptor cells. Moreover, retinal Müller glial cells express high-affinity FGF-receptors (FGFRs). Because these Müller cells do not express FGF9, a paracrine-type of signal transduction should be present concerning FGF9.

Cell Culturing, Yeast Two Hybridization, RNA Isolation, RT-PCR, Western Blotting, Southern Blotting, Northern Blotting, Cloning, RACE, In situ Hybridization, Tissue Extraction, Immunohistochemistry, Mutagenesis, In gel kinase assay, In vitro Transcription, In Vitro Translation, Proliferation assays, Tunnel assay are some molecular biology and biochemistry techniques we frequently use in our research.

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